What We Do
Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Recently, the roles of microtubules in the pathogenesis of cardiovascular diseases have become increasingly apparent. Our goals are:
To understand how microtubule dysfunction in cardiovascular cells contributes to cardiovascular disease development.
To elucidate the interplay between inflammation and microtubule function in the cardiovascular cells during pathogenesis of cardiovascular diseases.
To develop the translational aspects of targeting microtubule players to diagnose and treat cardiovascular diseases.
Tiling of heart tissue
Super-resolution image of cardiomyocyte
Scanning electron microscopy image of heart tissue
How We Do: Multidisciplinary Approaches
Cardiovascular disease models & associated in vivo assessments (atherosclerosis; myocardial infarction, cardiomyopathy, heart failure, sepsis).
Studies on clinical samples and clinical data.
Primary cell isolation and culture (e.g. cardiomyocyte, Smooth muscle cell, Macrophage).
Single cardiomyocyte physiology using IonOptix full calcium and contractility system.
Cell phenotyping using advanced microscopy, flow cytometry, and ImageStream.
Molecular biology.
Biochemical techniques.
Advanced proteomics, cross-omics.
Cell engineering using lentivirus and adenovirus transduction.
Genetics.
Bioinformatics.